Antioxidant and antiproliferative activities on prostate and cervical cultured cancer cells of five medicinal plant extracts from Burkina Faso

B BAYALA, TM ZOHONCON, FW DJIGMA, C NADEMBEGA, S BARON, JM LOBACCARO, J SIMPORE ; Int. J. Biol. Chem. Sci 14 (3), 652-663

https://www.ajol.info/index.php/ijbcs/article/view/196824

Abstract

Medicinal plants are a potential source of drug discovery and development of cancer chemoprevention drugs. Thus, the aim of this work was to study the antioxidant and antiproliferative activities of hydromethanolic extracts of Musa sapientum L., Cassia italica (Mill.) Spreng., Crateva adansonii DC., Euphorbia hirta L. and Ceratotheca sesamoides Endl. from Burkina Faso. The antioxidative activity of hydromethanolic extracts of plant was assessed using DPPH radical scavenging assay and ABTS+ radical cation decolorisation assay. Antiproliferative activity was evaluated by MTT assay. Of these five plant extracts, hydromethanolic extract of Euphorbia hirta leaf twigs showed the best antioxidant activity both by DPPH (IC50 = 0.53 ± 0.04 μg extract / μg DPPH) and ABTS (C = 0.302 ± 0.003 μMET / g extract) methods. In addition, hydromethanolic extract of Euphorbia hirta leaf twigs showed the best antiproliferative activity on LNCaP cell lines of prostate cancer while the hydromethanolic extract of the Ceratotheca sesamoides leaf stems showed the best antiproliferative activity on the HeLa cell lines of cervical cancer. This work has shown not only the antioxidant and anticancer activities of these five local plants, but also the potential valorization of these species used in traditional medicine in Burkina Faso.

Keywords  : Cancer, antioxydant, antiproliferative, Medicinal plants, Burkina Faso.



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