Polymorphism of MMP1 and MMP3 promoter regions and HR-HPV infection in women from Burkina Faso and Côte d’Ivoire.

Bado P, Djigma WF, Zohoncon TM, Obiri-Yeboah D, Traoré EMA, Ouattara AK, Ouedraogo TWC, Bello SOT, Setor MA, Traore IMA, Horo A, Kouakou KP, Yonli AT, Ouedraogo C, Simpore J.
Biomol Concepts. 2020 May 17 ;11(1):116-124. doi : 10.1515/bmc-2020-0010. PMID : 32417757



The single nucleotide polymorphism (SNP) of the promoter region of MMP-1 (at 1607 bp) and MMP-3 (at 1171 bp) create Ets binding sites. Correlations between these SNPs and sensitivity to several biological processes such as metastasis and recurrence of cancer have been reported in several studies. In this case-control study, we looked for these SNPs in women infected with or not with high-risk human papillomaviruses (HR-HPV). The frequency, distribution and correlation of these SNPs with the presence or absence of HR-HPV infection were evaluated. Genotypes 1G1G, 1G2G and 2G2G for MMP1 and genotypes 5A5A, 5A6A, 6A6A for MMP3 were found in our study population. In general, we noted that the 1G (40.8%) and 2G (64.8%) alleles were more frequent in non-infected women and infected women, respectively, and more specifically this difference was significant in women from Côte d’Ivoire. These results, although yet to be reaffirmed with assays for quantifying the mRNA of these genes, suggest that the SNP of the MMP-1 promoter could promote infection with HR-HPV.

Keywords : Cervix cancer ; High-risk HPV ; MMPs polymorphism ; mRNA expression.

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