Characterization of High-risk Oncogenic Human Papillomavirus Genotypes in Histologically Confirmed Ear, Nose and Throat (Ent) Cancers in Burkina Faso.

Ilboudo M, Zohoncon TM, Traore EMA, Traore IMA, Kande A, Djigma FW, Obiri-Yeboah D, Gyebre YMC, Simpore J. Asian Pac J Cancer Prev. 2019 Nov 1 ;20(11):3429-3435. doi : 10.31557/APJCP.2019.20.11.3429. PMID : 31759369
https://www.ncbi.nlm.nih.gov/pubmed/31759369
Abstract
BACKGROUND : High-risk human papillomavirus (HPV-HR) infections are responsible for 99.99% of cervico-uterine cancers and 50% of carcinomas of the oropharynx.
OBJECTIVE : To characterize high-risk HPV genotypes (HPV-HR) in histologically confirmed ear, nose and throat (ENT) cancers in Ouagadougou.
METHODS : One hundred and twenty-eight archived tissues from the ENT sphere, obtained over the last ten years (2007 to 2017) and histologically diagnosed in anatomy and pathology-cytology laboratories in Ouagadougou were included. These tissues were dewaxed with xylene ; HPV DNA extraction was performed and HPV-HR were researched by real-time multiplex PCR.
RESULTS : Among the fourteen HPV-HR genotypes tested for, seven were identified. The prevalence of HPV-HR infection was 15.6%. The most common genotypes were : HPV56 (45%) and HPV33 (20%). Squamous cell carcinomas accounted for 75% of cases, followed by lymphomas for 10%. The age range was between 5 and 80 years.
CONCLUSION : The results show the involvement of a diversity of HPV-HR genotypes and a high frequency of HPV56 and HPV33 in ENT cancers in Ouagadougou, Burkina Faso. The appropriate HPV vaccination will considerably reduce the number of these
KEYWORDS : (high-risk HPV ; Burkina Faso ; Carcinoma ; ENT ; Real-Time PCR



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