Insights into the Interplay between KIR Gene Frequencies and Chronic HBV Infection in Burkina Faso.

Sorgho PA, Martinson JJ, Djigma FW, Yonli AT, Nagalo BM, Compaore TR, Obiri-Yeboah D, Diarra B, Sombie HK, Zongo AW, Ouattara AK, Soubeiga STR, Traore L, Roberts LR, Simpore J. ; Mediterr J Hematol Infect Dis. 2018 Nov 1 ;10(1):e2018060. doi : 10.4084/MJHID.2018.060. eCollection 2018. ; PMID : 30416692

Background/Objective : Hepatitis B virus (HBV) infection is the leading risk factor for cirrhosis and hepatocellular carcinoma (HCC). The objective of this investigation was to assess the association between "Killer Cell Immunoglobulin-Like Receptor" (KIR) gene frequencies and chronic HBV infection.
Methods : Chronic HBV carriers and healthy patients were selected for this study. The viral load for HBV were performed, and SSP-PCR was used to characterize the frequencies of KIR genes.
Results : The study suggested that inhibitory genes KIR2DL2 (crude OR = 2.82 ; p < 0.001), KIR2DL3 (crude OR = 2.49 ; p < 0.001) and activator gene KIR2DS2 (crude OR = 3.95 ; p< 0.001) might be associated with chronic stages of HBV infection. Conversely the inhibitory genes KIR3DL1 (crude OR = 0.49 ; p = 0.0018) and KIR3DL2 (crude OR = 0.41 ; p = 0.005), the activator gene KIR2DS1 (crude OR = 0.48 ; p = 0.014) and the pseudo gene KIR2DP1 (crude OR = 0.49 ; p = 0.008) could be associated with immunity against HBV infection. Chronic HBV patients who are carriers for the KIR3DL3 gene (crude OR = 8 ; p = 0.048) were positive for HBeAg and patients who carried the KIR3DL2 gene (crude OR = 3.21 ; p = 0.012) had a high HBV viral load compared to the rest of the study population.
Conclusion : Our data showed evidence of a correlation between the risk of developing chronic HBV infection and certain KIR gene frequencies and also show that KIR3DL1, KIR3DL2, KIR2DS1 might confer a protective status against chronic HBV infection.
KEYWORDS : Burkina Faso ; Chronic Hepatitis B ; HBV ; KIR

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