Incompatible blood transfusion in children in Burkina Faso

Eléonore Kafando, Lady Rosny Wandji Nana, Yacouba Domo, Yacouba Nébié, Dorcas Obiri-Yeboah, Jacques Simporé
Open Journal of Hematology, 2017, 8-1 ;

Abstract :

Background : Transfusion therapy saves lives, but remains complicated by RBC immunization. So, erythrocyte phenotyping in blood donors and recipients is crucial in minimizing alloimmunization.

Objectives : To determine the frequency of Rhesus and Kell incompatible red blood cell transfusions in children.

Methods : A cross-sectional observational study was conducted in two paediatric health centres in Ouagadougou, Burkina Faso. Usually, standard phenotyping, ABO and RhD was determined for transfusion. Extended phenotyping i.e. RhC, RhE, Rhc, and Rhe and Kell antigens, was determined in both the recipients and the donor red blood cell units as well. The samples were analyzed using the LISS-Coombs indirect antiglobulin test to determine if alloimmunization had occurred.

Results:Out of the 474 transfused children, a haemoglobin level under 70g/L was observed in 86% of them, malaria (49%) was the main indication for blood transfusion and incompatible Rhesus /Kell transfusions were demonstrated in 25% of the cases. The red cell alloimmunization was observed in 4.2% of the patients.

Conclusions : Performing erythrocyte phenotyping in donors and recipients will diminish the risk of alloimmunization in children receiving multiple transfusions later in life.


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