Prevalence of hepatitis virus delta infection among HBVAgs positive blood donors at the Regional Blood Transfusion Center of Ouagadougou, Burkina Faso

Moutanou Modeste Judes ZEYE, Serge Potiandi DIAGBOUGA, Florencia Wendkuuni DJIGMA, Mahamoudou SANOU, DORCAS Obiri-Yeboah, Serge Yannick OUEDRAOGO, Abel Pegdwendé SORGHO, Abdoul Karim OUATTARA, Arsène Wendpagnangdé ZONGO, Abdoulaye TANGARA, Tegwindé Rébéca COMPAORE, Siaka OUATTARA, Jacques SIMPORE ;

International Journal of Microbiology and Immunology Research ; 5(1), 2017 ;
http://academeresearchjournals.org/download.php?id=646946946816370121.pdf&type=application/pdf&op=1

Abstract

Background : Infection with hepatitis viruses constitutes a public health problem in Burkina Faso. Several previous studies have estimated the prevalence of viral hepatitis A, B and C. This study aimed to study the prevalence of hepatitis delta infection in apparent healthy blood donors positive for the antigen of hepatitis B virus.

Methods : This study involved first time blood donors, positive for HBV surface antigen (HBsAg). The presence of HBV and HDV was confirmed using real time PCR duplex. The SPSS software was used for statistical analyzes of the obtained results.

Results : Two hundred HBsAg positive blood donors were enrolled in this study. The socio-demographic data showed 79% of men from all religious and ethnic denominations. RT-PCR analysis confirmed the presence of HBV DNA in 195/200 (97.5%) positive blood donors. Only 0.5% (1/200) of HBV positive person presented a case of co-infection with HDV.

Conclusion : Our study shows that 97.5% of HBsAg positive person detected by the ARCHITECT i 1000 SRTM were positive by PCR. The obtained results showed that the distribution of HDV in blood donors positive for the hepatitis B antigen is low (0.5%).

Key words : HBV, HDV, Real Time PCR, Blood donors, Ouagadougou, Burkina Faso.



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