The Modalities of Nonadherence to Highly Active Antiretroviral Therapy and the Associated Factors Related to Patients’ Sociodemographic Characteristics and Their Caregiving Perceptions in Ouagadougou (Burkina Faso).

Guira O, Kaboré DS, Dao G, Zagré N, Zohoncon TM, Pietra V, Drabo JY, Simporé J. J Int Assoc Provid AIDS Care. 2015 Nov 13. pii : 2325957415616492. PMID : 26567225

The authors studied the modalities of nonadherence to highly active antiretroviral therapy (HAART) and its sociodemographic associated factors and those in relation to caregiving perception in Ouagadougou.

A cross-sectional study was performed from December 2013 to February 2014 in 2 health centers. Adults receiving HAART for at least 3 months were included. Adherence was studied according to the quantitative, qualitative, and global criteria. Factors associated with nonadherence were analyzed with chi-square and Fisher tests. A logistic regression model was applied for multivariate analysis.

The authors studied 152 patients : mean age 40.7 ± 7.8 years and sex ratio 0.34. Frequencies were 7.2% for self-reported quantitative, 20.4% for calculated quantitative, 31.6% for qualitative, and 38.2% for global nonadherence. Married status (P = .02), patient’s dissatisfaction regarding clinical monitoring (P = .01), and therapeutic education (P = .03) were associated with nonadherence. In multivariate analysis, married status remains associated (odds ratio = 7.00, 95% confidence interval = 1.89-25.8, P = .0004).

Nonadherence to HAART needs to be correctly managed during HIV/AIDS monitoring.


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