Synchronic macrophage response and Plasmodium falciparum malaria.

Musumeci M, Simpore J, Barone R, Angius A, Musumeci S.

J Vector Borne Dis. 2006 Jun ;43(2):84-7. No abstract available. PMID : 16967821 [PubMed - indexed for MEDLINE]

Human Chitotriosidase (CHIT), produced by activated macrophage, is a member of the chitinase family, a group of enzymes with the capability to hydrolyze chitin1. Recently plasma CHIT activity was found elevated in children with acute P. falciparum malaria compared with healthy African children, as a consequence of macrophage activation due to the presence of parasites2. In this study we recruited at the local Centre Medical Saint Camille (CMSC) of Ouagadougou, the capital of Burkina
Faso, 62 African children (30 males and 32 females, aged 2–140 months ; median 16.5 months), affected by acute P. falciparum malaria, born and living in Burkina Faso. Control subjects included 140 healthy African children (79 males and 61 females) with age ranging from 10 to 100 months (median 22 months) at evaluation time. They did not show signs of acute infectious disease and their blood smears for P. falciparum were negative. This study was approved by the local Ethical Committees of CMSC. 

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